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https://doi.org/10.21256/zhaw-30148| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population |
| Authors: | Kirkeleit, Jorunn Riise, Trond Wielscher, Mathias Accordini, Simone Carsin, Anne-Elie Dratva, Julia Franklin, Karl A. Garcia-Aymerich, Judith Jarvis, Deborah Leynaert, Benedicte Lodge, Caroline J. Real, Francisco Gomez Schlünssen, Vivi Corsico, Angelo Guido Heinrich, Joachim Holm, Matthias Janson, Christer Benediktsdóttir, Bryndis Jogi, Rain Dharmage, Shyamali C. Järvelin, Marjo-Riitta Svanes, Cecilie |
| et. al: | No |
| DOI: | 10.1016/j.eclinm.2023.102339 10.21256/zhaw-30148 |
| Published in: | eClinicalMedicine |
| Volume(Issue): | 66 |
| Issue: | 102339 |
| Issue Date: | Dec-2023 |
| Publisher / Ed. Institution: | Elsevier |
| ISSN: | 2589-5370 |
| Language: | English |
| Subjects: | Accelerated decline; Early life risk factor; FEV1; FEV1/FVC ratio; FVC; Lung function; Maternal asthma; Maternal smoking; Paternal asthma |
| Subject (DDC): | 616: Internal medicine and diseases |
| Abstract: | Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/30148 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | School of Health Sciences |
| Organisational Unit: | Institute of Public Health (IPH) |
| Appears in collections: | Publikationen Gesundheit |
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| 2023_Kirkeleit-etal_Accelerated-lung-function-decline-in-adulthood.pdf | 429.15 kB | Adobe PDF |  View/Open |
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Kirkeleit, J., Riise, T., Wielscher, M., Accordini, S., Carsin, A.-E., Dratva, J., Franklin, K. A., Garcia-Aymerich, J., Jarvis, D., Leynaert, B., Lodge, C. J., Real, F. G., Schlünssen, V., Corsico, A. G., Heinrich, J., Holm, M., Janson, C., Benediktsdóttir, B., Jogi, R., et al. (2023). Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population. eClinicalMedicine, 66(102339). https://doi.org/10.1016/j.eclinm.2023.102339
Kirkeleit, J. et al. (2023) ‘Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population’, eClinicalMedicine, 66(102339). Available at: https://doi.org/10.1016/j.eclinm.2023.102339.
J. Kirkeleit et al., “Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population,” eClinicalMedicine, vol. 66, no. 102339, Dec. 2023, doi: 10.1016/j.eclinm.2023.102339.
KIRKELEIT, Jorunn, Trond RIISE, Mathias WIELSCHER, Simone ACCORDINI, Anne-Elie CARSIN, Julia DRATVA, Karl A. FRANKLIN, Judith GARCIA-AYMERICH, Deborah JARVIS, Benedicte LEYNAERT, Caroline J. LODGE, Francisco Gomez REAL, Vivi SCHLÜNSSEN, Angelo Guido CORSICO, Joachim HEINRICH, Matthias HOLM, Christer JANSON, Bryndis BENEDIKTSDÓTTIR, Rain JOGI, Shyamali C. DHARMAGE, Marjo-Riitta JÄRVELIN und Cecilie SVANES, 2023. Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population. eClinicalMedicine. Dezember 2023. Bd. 66, Nr. 102339. DOI 10.1016/j.eclinm.2023.102339
Kirkeleit, Jorunn, Trond Riise, Mathias Wielscher, Simone Accordini, Anne-Elie Carsin, Julia Dratva, Karl A. Franklin, et al. 2023. “Early Life Exposures Contributing to Accelerated Lung Function Decline in Adulthood : A Follow-up Study of 11,000 Adults from the General Population.” eClinicalMedicine 66 (102339). https://doi.org/10.1016/j.eclinm.2023.102339.
Kirkeleit, Jorunn, et al. “Early Life Exposures Contributing to Accelerated Lung Function Decline in Adulthood : A Follow-up Study of 11,000 Adults from the General Population.” eClinicalMedicine, vol. 66, no. 102339, Dec. 2023, https://doi.org/10.1016/j.eclinm.2023.102339.
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