Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-30272
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dc.contributor.authorCauquil, Eléonore-
dc.contributor.authorKiener, Luca-
dc.contributor.authorHofmann, Jonas-
dc.contributor.authorSpano, Fabrizio-
dc.contributor.authorRöhrnbauer, Barbara-
dc.date.accessioned2024-03-15T16:10:45Z-
dc.date.available2024-03-15T16:10:45Z-
dc.date.issued2023-09-
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30272-
dc.description.abstractSolid liquid composites are motivated by a variety of multi-physics applications including research in mechanobiology. From a mechanical perspective, liquid inclusions in a matrix affect both its global and local properties - the latter seen as local stiffness variations. It is known that stiffness variations in substrates are sensed by cells and incite cell migration so-called durotaxis. To investigate this complex interplay, detailed knowledge is needed on the local mechanical properties of the substrate. In this study, a combined experimental and numerical approach is proposed to characterize and tailor the local and global mechanical properties of a soft solid liquid composite. Polydimethylsiloxane (PDMS) membranes with a regular pattern of liquid inclusions of two different sizes (1.1mm, 0.5mm) were produced according to the procedure reported elsewhere. Planar tension tests were performed resulting in a biaxial state of stress, representative for loading conditions of biological membranes. After preconditioning during 9 cycles, samples were strained quasi-statically to 30% nominal strain. In addition to the global force and displacement data, local deformations were evaluated using a digital image correlation system. A numerical model based on a representative unit cell approach was built using a commercial finite element software. The unit cell was modeled as a 3D cuboid containing a spherical inclusion. For the PDMS, a Neo-Hookean material was chosen, which was fitted to test data of pure PDMS. The liquid inclusion was modeled using built-in element types. The model was validated applying both the global force response and the local deformation pattern. A numerical parameter study was performed, varying the size and density of the inclusions. The numerical model was shown to excellently reproduce both, the global force response, and the local deformation pattern (Figure). Apart from the parameter of the Neo-Hookean model, no fitting of parameters was needed resulting in a simple and robust modeling approach. The parameter study revealed the potential to tailor a wide variety of biaxial global stiffnesses (0.20-0.44 MPa) and to finetune local stiffness gradients. Current limitations are the reproducibility of the PDMS properties and the small experimental basis (n=3). However, the feasibility of the approach as well as the excellent predictive capabilities of the model have been shown. This experimental and numerical framework shall be used to investigate phenomena such as durotaxis incited by specifically tailored stiffness gradients and thus, contribute to quantitative research in mechanobiology.de_CH
dc.language.isoende_CH
dc.publisherZHAW Zürcher Hochschule für Angewandte Wissenschaftende_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectDigital image correlationde_CH
dc.subjectSolid liquid compositesde_CH
dc.subjectMulit-scale mechanicsde_CH
dc.subjectUnit cell modelde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titleA combined experimental and numerical method for tailoring the multi-scale mechanical properties of soft solid liquid compositesde_CH
dc.typeKonferenz: Posterde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Mechanische Systeme (IMES)de_CH
zhaw.organisationalunitInstitute of Computational Physics (ICP)de_CH
dc.identifier.doi10.21256/zhaw-30272-
zhaw.conference.details33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.webfeedBME Biomechanical Engineering - Soft Tissue Biomechanicsde_CH
zhaw.webfeedSensors and Measuring Systemsde_CH
zhaw.funding.zhawAuf dem Weg zu massgeschneiderten mechanischen Eigenschaften künstlicher Gewebemodellede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Cauquil, E., Kiener, L., Hofmann, J., Spano, F., & Röhrnbauer, B. (2023, September). A combined experimental and numerical method for tailoring the multi-scale mechanical properties of soft solid liquid composites. 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023. https://doi.org/10.21256/zhaw-30272
Cauquil, E. et al. (2023) ‘A combined experimental and numerical method for tailoring the multi-scale mechanical properties of soft solid liquid composites’, in 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023. ZHAW Zürcher Hochschule für Angewandte Wissenschaften. Available at: https://doi.org/10.21256/zhaw-30272.
E. Cauquil, L. Kiener, J. Hofmann, F. Spano, and B. Röhrnbauer, “A combined experimental and numerical method for tailoring the multi-scale mechanical properties of soft solid liquid composites,” in 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023, Sep. 2023. doi: 10.21256/zhaw-30272.
CAUQUIL, Eléonore, Luca KIENER, Jonas HOFMANN, Fabrizio SPANO und Barbara RÖHRNBAUER, 2023. A combined experimental and numerical method for tailoring the multi-scale mechanical properties of soft solid liquid composites. In: 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023. Conference poster. ZHAW Zürcher Hochschule für Angewandte Wissenschaften. September 2023
Cauquil, Eléonore, Luca Kiener, Jonas Hofmann, Fabrizio Spano, and Barbara Röhrnbauer. 2023. “A Combined Experimental and Numerical Method for Tailoring the Multi-Scale Mechanical Properties of Soft Solid Liquid Composites.” Conference poster. In 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023. ZHAW Zürcher Hochschule für Angewandte Wissenschaften. https://doi.org/10.21256/zhaw-30272.
Cauquil, Eléonore, et al. “A Combined Experimental and Numerical Method for Tailoring the Multi-Scale Mechanical Properties of Soft Solid Liquid Composites.” 33rd Annual Conference of the European Society for Biomaterials (ESB), Davos, Switzerland, 4-8 September 2023, ZHAW Zürcher Hochschule für Angewandte Wissenschaften, 2023, https://doi.org/10.21256/zhaw-30272.


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