Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents

Miron, A.; Aelenei, P.; Trifan, A.; Rimbu, C.M.; Horhogea, C.E.; Luca, S.V.; Neagu, A.N.; Wolfram, E.; Aprotosoaie, A.C.

doi:10.1055/s-0039-3399721

Publication type:	Conference other
Type of review:	Peer review (abstract)
Title:	Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents
Authors:	Miron, A. Aelenei, P. Trifan, A. Rimbu, C.M. Horhogea, C.E. Luca, S.V. Neagu, A.N. Wolfram, E. Aprotosoaie, A.C.
et. al:	No
DOI:	10.1055/s-0039-3399721
Proceedings:	Planta Medica
Volume(Issue):	85
Issue:	18
Page(s):	1422
Conference details:	67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, Innsbruck, Austria, 1-5 September 2019
Issue Date:	4-Sep-2019
Publisher / Ed. Institution:	Thieme
ISSN:	1439-0221
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics
Abstract:	Combination of conventional antibiotics with natural products represents a promising strategy in overcoming antibiotic resistance. The aim of this work was to assess the interactions between plant-derived products and several antibiotics in order to identify potential synergistic antibacterial combinations. Both extracts and pure phytochemicals were included in this study. The effects of the combinations were evaluated against Gram-positive including methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria. Our studies on essential oils showed that coriander essential oil and its major constituent, linalool, acted synergistically with several antibiotics (oxacillin, gentamicin, tetracycline, ciprofloxacin) against both Gram-positive and Gram-negative bacteria with coriander essential oil reversing tetracycline resistance of Staphylococcus epidermitis [2]. Despite its moderate antibacterial activity, white mulberry leaf ethanolic extract was found to reverse oxacillin resistance of MRSA and to act synergistically with gentamicin against MRSA. Additionally, the extract showed synergy with gentamicin and tetracycline against Staphylococcus epidermitis [3]. Two of its constituents, namely morusin and kuwanon G, also reversed oxacillin resistance of MRSA and acted synergistically with gentamicin, tetracycline and ciprofloxacin against MRSA. Morusin also reversed tetracycline resistance of Staphylococcus epidermitis. Both morusin and kuwanon G increased the permeability of the bacterial membrane as shown by fluorescence and differential interference contrast microscopy. Conclusion: Plant-derived products are promising candidates for the development of novel treatment strategies in bacterial infections.
URI:	https://digitalcollection.zhaw.ch/handle/11475/30381
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Miron, A., Aelenei, P., Trifan, A., Rimbu, C. M., Horhogea, C. E., Luca, S. V., Neagu, A. N., Wolfram, E., & Aprotosoaie, A. C. (2019). Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents [Conference presentation]. Planta Medica, 85(18), 1422. https://doi.org/10.1055/s-0039-3399721

Miron, A. et al. (2019) ‘Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents’, in Planta Medica. Thieme, p. 1422. Available at: https://doi.org/10.1055/s-0039-3399721.

A. Miron et al., “Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents,” in Planta Medica, Sep. 2019, vol. 85, no. 18, p. 1422. doi: 10.1055/s-0039-3399721.

MIRON, A., P. AELENEI, A. TRIFAN, C.M. RIMBU, C.E. HORHOGEA, S.V. LUCA, A.N. NEAGU, E. WOLFRAM und A.C. APROTOSOAIE, 2019. Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents. In: Planta Medica. Conference presentation. Thieme. 4 September 2019. S. 1422

Miron, A., P. Aelenei, A. Trifan, C.M. Rimbu, C.E. Horhogea, S.V. Luca, A.N. Neagu, E. Wolfram, and A.C. Aprotosoaie. 2019. “Plant-Derived Products as Antibiotic Enhancers and Antibiotic-Resistance Modifying Agents.” Conference presentation. In Planta Medica, 85:1422. Thieme. https://doi.org/10.1055/s-0039-3399721.

Miron, A., et al. “Plant-Derived Products as Antibiotic Enhancers and Antibiotic-Resistance Modifying Agents.” Planta Medica, vol. 85, no. 18, Thieme, 2019, p. 1422, https://doi.org/10.1055/s-0039-3399721.