Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study

Künzler-Heule, Patrizia; Schmidt, Axel J.; Fierz, Katharina; Battegay, Manuel; Engberg, Sandra; Kouyos, Roger D.; Nöstlinger, Christiana; Stöckle, Marcel; Béguelin, Charles; Delaloye, Julie; Schmid, Patrick; Rougemont, Mathieu; Braun, Dominique L.; Fehr, Jan S.; Nicca, Dunja

doi:10.1080/09540121.2023.2208318

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study
Authors:	Künzler-Heule, Patrizia Schmidt, Axel J. Fierz, Katharina Battegay, Manuel Engberg, Sandra Kouyos, Roger D. Nöstlinger, Christiana Stöckle, Marcel Béguelin, Charles Delaloye, Julie Schmid, Patrick Rougemont, Mathieu Braun, Dominique L. Fehr, Jan S. Nicca, Dunja
et. al:	Yes
DOI:	10.1080/09540121.2023.2208318
Published in:	AIDS Care
Volume(Issue):	36
Issue:	4
Page(s):	442
Pages to:	451
Issue Date:	Apr-2024
Publisher / Ed. Institution:	Taylor & Francis
ISSN:	0954-0121 1360-0451
Language:	English
Subjects:	HIV infection; Homosexuality; NCT02785666; Harm reduction; Hepatitis C; Sex counselling; Male; Humans; Hepacivirus; Homosexuality, Male; Reinfection; Sexual behavior; Risk reduction behavior; Hepatitis C
Subject (DDC):	614: Public health and prevention of disease 616: Internal medicine and diseases
Abstract:	To prevent hepatitis C virus (HCV) reinfection, within the Swiss HCVree Trial, a preventive risk reduction intervention was implemented alongside curative treatment. Formative qualitative research identified three response patterns to the intervention. This mixed-methods study's aim was to cross-validate group differences in (a) the content of sexual risk reduction goals set during intervention and (b) the extent of their behavioural change in condomless anal intercourse with non-steady partners (nsCAI), sexualised and intravenous drug use at start and six-month post-intervention. Qualitative thematic analysis was used to summarise goal setting domains. Quantitative descriptive analysis was used to evaluate group differences based on assumptions of the group descriptions. Results largely confirmed assumptions on inter-group response differences in goal setting and behaviour: as expected group 1 Avoid risks showed the lowest HCV risk profile with changes in nsCAI. Group 2 Minimize-risks and Group 3 Accept-risks showed unchanged nsCAI. Group 3 had the highest HCV risk profile. Differences in their goal preferences (1: condom use; 2 reduction blood exposure; 3 safer dating) highlight diversity in attitudes to behavioural change. Our results improve understanding of variability in intervention responses such as changes in attitudes and behaviour. This provides evidence for intervention tailoring and outcome measurement.
URI:	https://researchonline.lshtm.ac.uk/id/eprint/4671693/2/Kunzler-Heule-etal-2023-Group-differences-sexual-risk-reduction.pdf https://digitalcollection.zhaw.ch/handle/11475/30776
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Nursing (IPF)
Appears in collections:	Publikationen Gesundheit

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Künzler-Heule, P., Schmidt, A. J., Fierz, K., Battegay, M., Engberg, S., Kouyos, R. D., Nöstlinger, C., Stöckle, M., Béguelin, C., Delaloye, J., Schmid, P., Rougemont, M., Braun, D. L., Fehr, J. S., & Nicca, D. (2024). Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study. AIDS Care, 36(4), 442–451. https://doi.org/10.1080/09540121.2023.2208318

Künzler-Heule, P. et al. (2024) ‘Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study’, AIDS Care, 36(4), pp. 442–451. Available at: https://doi.org/10.1080/09540121.2023.2208318.

P. Künzler-Heule et al., “Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study,” AIDS Care, vol. 36, no. 4, pp. 442–451, Apr. 2024, doi: 10.1080/09540121.2023.2208318.

KÜNZLER-HEULE, Patrizia, Axel J. SCHMIDT, Katharina FIERZ, Manuel BATTEGAY, Sandra ENGBERG, Roger D. KOUYOS, Christiana NÖSTLINGER, Marcel STÖCKLE, Charles BÉGUELIN, Julie DELALOYE, Patrick SCHMID, Mathieu ROUGEMONT, Dominique L. BRAUN, Jan S. FEHR und Dunja NICCA, 2024. Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM : a mixed-methods study. AIDS Care [online]. April 2024. Bd. 36, Nr. 4, S. 442–451. DOI 10.1080/09540121.2023.2208318. Verfügbar unter: https://researchonline.lshtm.ac.uk/id/eprint/4671693/2/Kunzler-Heule-etal-2023-Group-differences-sexual-risk-reduction.pdf

Künzler-Heule, Patrizia, Axel J. Schmidt, Katharina Fierz, Manuel Battegay, Sandra Engberg, Roger D. Kouyos, Christiana Nöstlinger, et al. 2024. “Exploring Group Differences in the Response to a Sexual Risk Reduction Intervention to Prevent Hepatitis C Virus Reinfection in HIV-Infected MSM : A Mixed-Methods Study.” AIDS Care 36 (4): 442–51. https://doi.org/10.1080/09540121.2023.2208318.

Künzler-Heule, Patrizia, et al. “Exploring Group Differences in the Response to a Sexual Risk Reduction Intervention to Prevent Hepatitis C Virus Reinfection in HIV-Infected MSM : A Mixed-Methods Study.” AIDS Care, vol. 36, no. 4, Apr. 2024, pp. 442–51, https://doi.org/10.1080/09540121.2023.2208318.