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dc.contributor.authorTeuffel, O.-
dc.contributor.authorBetts, D. R.-
dc.contributor.authorDettling, Marcel-
dc.contributor.authorSchaub, R.-
dc.contributor.authorSchäfer, B. W.-
dc.contributor.authorNiggli, F. K.-
dc.date.accessioned2018-04-03T15:18:08Z-
dc.date.available2018-04-03T15:18:08Z-
dc.date.issued2004-
dc.identifier.issn0887-6924de_CH
dc.identifier.issn1476-5551de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/4656-
dc.description.abstractSeveral studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia (ALL) frequently arises before birth. A prenatal origin of childhood leukemia was further supported by the detection of clonotypic immunoglobulin gene rearrangements on neonatal blood spots of children with various other subtypes of ALL. However, no comprehensive study is available linking these clonotypic events. We describe a pair of 5-year-old monozygotic twins with concordant TEL-AML1-positive ALL. Separate leukemic clones were identified in the diagnostic samples since distinct IGH and IGK-Kde gene rearrangements could be detected. Additional differences characterizing the leukemic clones included an aberration of the second, nonrearranged TEL allele observed in one twin only. Interestingly, both the identical TEL-AML1 fusion sequence and distinct immunoglobulin gene rearrangements were identified on the neonatal blood spots indicating that separate preleukemic clones evolved already before birth. Finally, we compared the reported twins with an additional 31 children with ALL by using the microarray technology. Gene expression profiling provided evidence that leukemia in twins harbours the same subtype-typical feature as TEL-AML1-positive leukemia in singletons suggesting that the leukemogenesis model might also be applicable generally.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofLeukemiade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBase sequencede_CH
dc.subjectChild, preschoolde_CH
dc.subjectCore binding factor alpha 2 subunitde_CH
dc.subjectDiseases in twinsde_CH
dc.subjectFemalede_CH
dc.subjectGene expression profilingde_CH
dc.subjectHumansde_CH
dc.subjectIn situ hybridization, fluorescencede_CH
dc.subjectMolecular sequence datade_CH
dc.subjectOncogene proteins, fusionde_CH
dc.subjectPhylogenyde_CH
dc.subjectPrecursor cell lymphoblastic leukemia-lymphomade_CH
dc.subjectSequence homology, nucleic acidde_CH
dc.subjectGene rearrangementde_CH
dc.subjectGenes, immunoglobulinde_CH
dc.subjectTwins, monozygoticde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titlePrenatal origin of separate evolution of leukemia in identical twinsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.publisher.placeLondonde_CH
dc.identifier.doi10.1038/sj.leu.2403462de_CH
dc.identifier.pmid15356660de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1629de_CH
zhaw.pages.start1624de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume18de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Teuffel, O., Betts, D. R., Dettling, M., Schaub, R., Schäfer, B. W., & Niggli, F. K. (2004). Prenatal origin of separate evolution of leukemia in identical twins. Leukemia, 18, 1624–1629. https://doi.org/10.1038/sj.leu.2403462
Teuffel, O. et al. (2004) ‘Prenatal origin of separate evolution of leukemia in identical twins’, Leukemia, 18, pp. 1624–1629. Available at: https://doi.org/10.1038/sj.leu.2403462.
O. Teuffel, D. R. Betts, M. Dettling, R. Schaub, B. W. Schäfer, and F. K. Niggli, “Prenatal origin of separate evolution of leukemia in identical twins,” Leukemia, vol. 18, pp. 1624–1629, 2004, doi: 10.1038/sj.leu.2403462.
TEUFFEL, O., D. R. BETTS, Marcel DETTLING, R. SCHAUB, B. W. SCHÄFER und F. K. NIGGLI, 2004. Prenatal origin of separate evolution of leukemia in identical twins. Leukemia. 2004. Bd. 18, S. 1624–1629. DOI 10.1038/sj.leu.2403462
Teuffel, O., D. R. Betts, Marcel Dettling, R. Schaub, B. W. Schäfer, and F. K. Niggli. 2004. “Prenatal Origin of Separate Evolution of Leukemia in Identical Twins.” Leukemia 18: 1624–29. https://doi.org/10.1038/sj.leu.2403462.
Teuffel, O., et al. “Prenatal Origin of Separate Evolution of Leukemia in Identical Twins.” Leukemia, vol. 18, 2004, pp. 1624–29, https://doi.org/10.1038/sj.leu.2403462.


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