Geography of lumbar paravertebral muscle fatty infiltration

Crawford, Rebecca J.; Volken, Thomas; Mhuiris, Áine Ni; Bow, Cora C.; Elliott, James M.; Hoggarth, Mark A; Samartzis, Dino

doi:10.1097/BRS.0000000000003060

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3231

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Geography of lumbar paravertebral muscle fatty infiltration
Authors:	Crawford, Rebecca J. Volken, Thomas Mhuiris, Áine Ni Bow, Cora C. Elliott, James M. Hoggarth, Mark A Samartzis, Dino
DOI:	10.1097/BRS.0000000000003060 10.21256/zhaw-3231
Published in:	Spine
Issue Date:	2019
Publisher / Ed. Institution:	Lippincott Williams & Wilkins
ISSN:	0362-2436 1528-1159
Language:	English
Subjects:	Paravertebral; Muscle; Multifidus; Low back pain; Disability; Disc degeneration; Phenotype; Fatty infiltration
Subject (DDC):	616.7: Diseases of musculoskeletal system and orthopaedics
Abstract:	Study Design: Cross-sectional Objective: We quantified fatty infiltration (FI) geography of the lumbar spine to identify whether demographics, temporal low back pain (LBP), and disability influence FI patterns. Summary of Background Data: Lumbar paravertebral muscle FI has been associated with age, sex, LBP, and disability; yet, FI accumulation patterns are inadequately described to optimise interventions. Methods: This cross-sectional study employed lumbar axial T1-weighted MRI in 107 Southern-Chinese adults (54 females, 53 males). Single-slices at the vertebral inferior end-plate per lumbar level were measured for quartiled-FI, and analysed against demographics, LBP, and disability (ODI: Oswestry Disability Index). Results: Mean FI% was higher in females, on the right, increased per level caudally, and from medial to lateral in men (p < 0.05). FI linearly increased with age for both sexes (p < 0.01) and was notably higher at L4&5 than L1,2&3 for cases aged 40-65yrs. BMI and FI were unrelated in females and inversely in males (p < 0.001). Females with LBPweek and males with LBPyear had 1.7% (each) less average FI (p < 0.05) than those without pain at that time-point. Men locating their LBP in the back had less FI than those without pain (p < 0.001). Disability was unrelated to FI for both sexes (p > 0.05). Conclusions: Lumbar paravertebral muscle FI predominates in the lower lumbar spine, notably for those aged 40-65, and depends more on sagittal than transverse distribution. Higher FI in females and differences of mean FI between sexes for BMI, LBP, and disabling ODI suggest sex-differential accumulation patterns. Our study contradicts pain models rationalising lumbar muscle FI and may reflect a normative sex-dependent feature of the natural history of lumbar paravertebral muscles.
URI:	https://digitalcollection.zhaw.ch/handle/11475/17230
Fulltext version:	Accepted version
License (according to publishing contract):	CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Restricted until:	2020-07-01
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

Files in This Item:

File	Description	Size	Format
geography_of_lumbar_paravertebtral_muscle_fatty_infiltration.pdf	Accepted Version	570.12 kB	Adobe PDF	View/Open

Show full item record

Crawford, R. J., Volken, T., Mhuiris, Á. N., Bow, C. C., Elliott, J. M., Hoggarth, M. A., & Samartzis, D. (2019). Geography of lumbar paravertebral muscle fatty infiltration. Spine. https://doi.org/10.1097/BRS.0000000000003060

Crawford, R.J. et al. (2019) ‘Geography of lumbar paravertebral muscle fatty infiltration’, Spine [Preprint]. Available at: https://doi.org/10.1097/BRS.0000000000003060.

R. J. Crawford et al., “Geography of lumbar paravertebral muscle fatty infiltration,” Spine, 2019, doi: 10.1097/BRS.0000000000003060.

CRAWFORD, Rebecca J., Thomas VOLKEN, Áine Ni MHUIRIS, Cora C. BOW, James M. ELLIOTT, Mark A HOGGARTH und Dino SAMARTZIS, 2019. Geography of lumbar paravertebral muscle fatty infiltration. Spine. 2019. DOI 10.1097/BRS.0000000000003060

Crawford, Rebecca J., Thomas Volken, Áine Ni Mhuiris, Cora C. Bow, James M. Elliott, Mark A Hoggarth, and Dino Samartzis. 2019. “Geography of Lumbar Paravertebral Muscle Fatty Infiltration.” Spine. https://doi.org/10.1097/BRS.0000000000003060.

Crawford, Rebecca J., et al. “Geography of Lumbar Paravertebral Muscle Fatty Infiltration.” Spine, 2019, https://doi.org/10.1097/BRS.0000000000003060.