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https://doi.org/10.21256/zhaw-4097| Publication type: | Conference paper |
| Type of review: | Peer review (abstract) |
| Title: | Dynamical stability of autocatalytic sets |
| Authors: | Füchslin, Rudolf Marcel Filisetti, Alessandro Serra, Roberto Villani, Marco DeLucrezia, Davide Poli, Irene |
| DOI: | 10.21256/zhaw-4097 |
| Proceedings: | Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems |
| Editors of the parent work: | Fellermann, Harold Dörr, Marc Hanczyc, Martin M. Ladegaard Laursen, Lone Maurer, Sarah Merkle, Daniel Monnard, Pierre Alain Støy, Kasper Rasmussen, Steen |
| Page(s): | 65 |
| Pages to: | 72 |
| Conference details: | The 12th International Conference on the Synthesis and Simulation of Living Systems, Odense, Denmark, 19-23 August 2010 |
| Issue Date: | 2010 |
| Series: | Artificial life |
| Series volume: | 12 |
| Publisher / Ed. Institution: | MIT Press |
| Publisher / Ed. Institution: | Cambridge |
| ISBN: | 978-0-262-29075-3 |
| Language: | English |
| Subjects: | Autocatalytic sets; Autocatalytic metabolism; Origin of life |
| Subject (DDC): | 540: Chemistry 570: Biology |
| Abstract: | Theoretical investigations of autocatalytic sets rendered the occurrence of self-sustaining sets of molecules to be a generic property of random reaction networks. This stands in some contrast to the experimental difficulty to actually find such systems. In this work, we argue that the usual approach, which is based on the study of static properties of reaction graphs has to be complemented with a dynamic perspective in order to avoid overestimation of the probability of getting autocatalytic sets. Especially under the, from the experimental point of view, important flow reactor conditions, it is not sufficient just to have a pathway generating a given type of molecules. The respective process has also to happen with a sufficient rate in order to compensate the outflow. Reaction rates are therefore of crucial importance. Furthermore, processes such as cleavage are on one hand advantageous for the system, because they enhance the molecular variability and therefore the potential for catalysis. On the other hand, cleavage may also act in an inhibiting manner by the destruction of vital components: therefore, an optimal balance between ligation and cleavage has to be found. If energy is included as a limiting resource, the concentration profiles of the components of autocatalytic sets are altered in a manner that renders a certain range for the energy supply rate as optimal for the realization of robust autocatalytic sets. The results presented are based on a theoretical model and obtained by numerical integration of systems of ODE. This limits the number of involved molecular species which implies that the quantitative findings of this work may have no direct relevance for experimental situations, whereas the qualitative insights in the dynamics of the systems under consideration may generalize to systems of truly combinatorial size. |
| Further description: | Open Access Publikation |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2722 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY-NC-ND 3.0: Attribution - Non commercial - No derivatives 3.0 Unported |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Applied Mathematics and Physics (IAMP) |
| Appears in collections: | Publikationen School of Engineering |
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| 2010_Fuechslin_Dynamical stability of autocatalytic sets_Artificial live XII.pdf | 118.04 kB | Adobe PDF |  View/Open |
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Füchslin, R. M., Filisetti, A., Serra, R., Villani, M., DeLucrezia, D., & Poli, I. (2010). Dynamical stability of autocatalytic sets [Conference paper]. In H. Fellermann, M. Dörr, M. M. Hanczyc, L. Ladegaard Laursen, S. Maurer, D. Merkle, P. A. Monnard, K. Støy, & S. Rasmussen (Eds.), Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems (pp. 65–72). MIT Press. https://doi.org/10.21256/zhaw-4097
Füchslin, R.M. et al. (2010) ‘Dynamical stability of autocatalytic sets’, in H. Fellermann et al. (eds) Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems. Cambridge: MIT Press, pp. 65–72. Available at: https://doi.org/10.21256/zhaw-4097.
R. M. Füchslin, A. Filisetti, R. Serra, M. Villani, D. DeLucrezia, and I. Poli, “Dynamical stability of autocatalytic sets,” in Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems, 2010, pp. 65–72. doi: 10.21256/zhaw-4097.
FÜCHSLIN, Rudolf Marcel, Alessandro FILISETTI, Roberto SERRA, Marco VILLANI, Davide DELUCREZIA und Irene POLI, 2010. Dynamical stability of autocatalytic sets. In: Harold FELLERMANN, Marc DÖRR, Martin M. HANCZYC, Lone LADEGAARD LAURSEN, Sarah MAURER, Daniel MERKLE, Pierre Alain MONNARD, Kasper STØY und Steen RASMUSSEN (Hrsg.), Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems. Conference paper. Cambridge: MIT Press. 2010. S. 65–72. ISBN 978-0-262-29075-3
Füchslin, Rudolf Marcel, Alessandro Filisetti, Roberto Serra, Marco Villani, Davide DeLucrezia, and Irene Poli. 2010. “Dynamical Stability of Autocatalytic Sets.” Conference paper. In Artificial Live XII : Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems, edited by Harold Fellermann, Marc Dörr, Martin M. Hanczyc, Lone Ladegaard Laursen, Sarah Maurer, Daniel Merkle, Pierre Alain Monnard, Kasper Støy, and Steen Rasmussen, 65–72. Cambridge: MIT Press. https://doi.org/10.21256/zhaw-4097.
Füchslin, Rudolf Marcel, et al. “Dynamical Stability of Autocatalytic Sets.” Artificial Live XII : Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems, edited by Harold Fellermann et al., MIT Press, 2010, pp. 65–72, https://doi.org/10.21256/zhaw-4097.
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